Yong Sang Jo

This paper identifies a self-limiting orexin-habenula circuit that promotes stress resilience by modulating dopamine and coping behaviors, and shows that chronic stress disrupts this circuit through epigenetic and inflammatory mechanisms.

This study shows that parabrachial CGRP neurons can regulate both freezing and fleeing behaviors in response to threat, expanding their known role in the alarm system.

The paper shows that CGRPPBel neurons encode opposing valence through frequency-dependent differential release of glutamate and neuropeptides in response to aversive and appetitive stimuli.

This study shows that recalling a positive reward-associated stimulus can suppress fear generalization in mice, involving dopamine and central amygdala mechanisms.

This study shows that Kv4.3 and BKCa1.1 ion channels regulate dopamine neuron firing and release on different time scales, influencing distinct phases of reinforced behavior in mice.

The paper identifies KOR/Dyn signaling in the midbrain as promoting threat generalization, showing an inverted U relationship between threat intensity and discrimination.