Hyun Woo Lee

A self-limiting orexin-habenula circuit for stress resilience

This paper identifies a self-limiting orexin-habenula circuit that promotes stress resilience by modulating dopamine and coping behaviors, and shows that chronic stress disrupts this circuit through epigenetic and inflammatory mechanisms.

Fusobacterium nucleatum produces previously unappreciated AHR-activating metabolites and promotes CRC cell proliferation via the AHR-TERT axis

This study identifies Fusobacterium nucleatum-produced indole metabolites that activate the AHR-TERT axis, promoting CRC cell proliferation and revealing FTIN as a potential biomarker.

Target-enhanced whole-genome sequencing (TE-WGS) shows clinical validity equivalent to commercially available targeted oncology panel

This study compares target-enhanced whole-genome sequencing (TE-WGS) with a commercial targeted panel, showing TE-WGS detects all variants and provides additional clinical insights.

Clinical application of whole-genome sequencing for precision oncology of solid tumors

This study evaluates the clinical utility of whole-genome sequencing in solid tumors, showing 72% of reports provided clinically relevant insights and 69% aided therapeutic decision-making.

Neural mechanism of acute stress management by trace aminergic signalling in the lateral habenula

This study identifies a novel LHb-RMTg pathway where trace aminergic signalling prevents VTA dopaminergic hypoactivity during acute stress, suggesting TAAR1 as a therapeutic target.