L Mitchell

A novel pH-sensitive probe to quantify autophagy on high throughput/content imaging platforms

This paper introduces a pH-sensitive fluorescent probe, CalRexin:pHrodo Red, for detecting autophagy through high throughput imaging and validates its utility in screening autophagy modulators.

Neuropilin 2 stabilises adherens junctions and protects against endothelial activation by promoting the interaction between VE cadherin and p120 catenin

This study shows that Nrp2 stabilizes adherens junctions in endothelial cells by promoting VE cadherin-p120 catenin interaction, preventing endothelial activation and vascular disease.