CAR T cells targeting Nectin-4 safely overcome resistance to anti-Nectin-4 antibody-drug conjugate in solid tumors
Alexandrine Faivre, Léa Laban, Lorène Ferreira, Emmanuelle Josselin, Laurent Gorvel, Emilie Agavnian, Anne K. Farina, Anne-Sophie Chrétien, Els Verhoeyen, Rémy Castellano, Jacques A. Nunès, Geoffrey C. Guittard, Marc Lopez, Daniel Olive
This study develops N4CART cells targeting Nectin-4 that overcome resistance to EV in solid tumors and show safety by avoiding skin toxicity.
bioRxiv · Sep 30, 2025 · PreprintImmunology