Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme
J. A. Kaczmarski, M. C. Mahawaththa, A. Feintuch, B. E. Clifton, L. A. Adams, D. Goldfarb, G. Otting, C. J. Jackson
The paper investigates how remote mutations alter conformational sampling along an evolutionary trajectory, increasing catalytic activity in an enzyme.
bioRxiv · Feb 3, 2020Biochemistry