J. A. Kaczmarski

The paper describes how two distinct enzymes evolved from a common ancestor through different mutational paths, leading to divergent molecular and phenotypic outcomes.

This paper investigates how trimerization and a C-terminal extension optimized the catalytic activity of cyclohexadienyl dehydratase through evolutionarily metastable oligomeric states.

This study identifies SbtB as a regulator of bicarbonate transporter SbtA activity in cyanobacteria, showing its response to adenylate energy charge through adenylnucleotide-mediated binding.

The paper investigates how remote mutations alter conformational sampling along an evolutionary trajectory, increasing catalytic activity in an enzyme.

This paper investigates how the PII-like protein SbtB regulates the bicarbonate transporter SbtA in Cyanobium sp. PCC7001 through allosteric interactions involving nucleotides and calcium.

The paper investigates how T-dependent B cells produce antibodies that form a high-avidity multivalent complex with Plasmodium falciparum CSP, revealing structural and immunological insights.