Author

L. A. Draper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Assay:metagenomics· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Hill· 6 shared R. P. Ross· 4 shared A. Shkoporov· 3 shared F. J. Ryan· 3 shared S. R. Stockdale· 3 shared A. G. Clooney· 2 shared E. Guerin· 2 shared E. V. Khokhlova· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersMicrobiology

C. Hill

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors

R. Singh, V. Rossini, S. R. Stockdale, G. Saiz-Gonzalo, N. Hanrahan, T. D' Souza, A. Clooney, L. A. Draper, C. Hill, K. Nally, F. Shanahan, S. Andersson-Engels, S. Melgar

The paper shows that AIEC synergizes with NSAID to worsen colitis in IL10 -/- mice, which is blocked by NLRP3 and Caspase-8 inhibitors.

bioRxiv · Aug 18, 2022Immunology

Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson's disease

S. R. Stockdale, L. A. Draper, S. O'Donovan, W. Barton, O. O'Sullivan, L. A. Volpicelli-Daley, A. Sullivan, C. O'Neill, C. Hill

This study shows that alpha-synuclein treatment in rats alters their faecal virome, with changes persisting over five months and influenced by LPS.

bioRxiv · Mar 29, 2021 · PreprintMicrobiology

The human gut virome is highly diverse, stable and individual-specific

A. Shkoporov, A. G. Clooney, T. D. S. Sutton, F. J. Ryan, K. M. Daly, J. A. Nolan, S. A. McDonnell, E. V. Khokhlova, L. A. Draper, A. Forde, E. Guerin, R. P. Ross, C. Hill

This study characterizes the human gut virome, revealing its high diversity, stability, and individual specificity through longitudinal metagenomic analysis of faecal samples.

bioRxiv · Jun 3, 2019Microbiology

Autochthonous faecal virome transplantation (FVT) reshapes the murine microbiome after antibiotic perturbation

L. A. Draper, F. J. Ryan, M. Dalmasso, P. G. Casey, A. McCann, V. Velayudhan, R. P. Ross, C. Hill

This study shows that transplanting an autochthonous faecal virome can reshape the murine microbiome after antibiotic treatment, restoring it closer to its pre-treatment state.

bioRxiv · Apr 2, 2019Microbiology

ΦCrAss001, a member of the most abundant bacteriophage family in the human gut, infects Bacteroides

A. Shkoporov, E. V. Khokhlova, C. B. Fitzgerald, S. R. Stockdale, L. A. Draper, R. P. Ross, C. Hill

The paper isolates and characterizes ΦCrAss001, a crAssphage infecting Bacteroides intestinalis, showing its genome structure and replication without lysogeny.

Nature Communications · Nov 14, 2018Peer-reviewedMicrobiology

Biology and taxonomy of crAss-like bacteriophages, the most abundant virus in the human gut

E. Guerin, A. Shkoporov, S. Stockdale, A. G. Clooney, F. J. Ryan, T. D. S. Sutton, L. A. Draper, E. Gonzalez-Tortuero, R. P. Ross, C. Hill

This study identifies and classifies crAss-like bacteriophages from human gut metagenomes, achieving their propagation and visualization.

bioRxiv · Apr 16, 2018Microbiology