Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
L. Zhang, M. Mann, Z. Syed, H. M. Reynolds, E. Tian, N. L. Samara, D. C. Zeldin, L. A. Tabak, K. G. Ten Hagen
This study shows that O-glycosylation near the furin cleavage site of SARS-CoV-2 spike protein reduces furin cleavage and is mediated by GALNT enzymes and a proline at position 681.
bioRxiv · Feb 5, 2021Biochemistry