Author

L. Aragon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Organism:human· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Assay:Hi-C· 1

Frequent Co-Authors

D. S. Rueda· 2 shared E. Cutts· 2 shared A. Llauro· 1 shared A. Montoya· 1 shared A. Thierry· 1 shared C. Cawood· 1 shared D. Rueda· 1 shared D. Tetiker· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

D. S. Rueda

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Author profile →

5 papers

Recent·Most cited

Molecular Mechanism of Condensin I Activation by KIF4A

E. E. Cutts, D. Tetiker, E. Kim, L. Aragon

The paper identifies a conserved mechanism by which KIF4A activates condensin I through direct binding to NCAPG and displacement of auto-inhibitory interactions.

bioRxiv · Mar 19, 2024Biochemistry

Substrate accessibility regulation of human TopIIa decatenation by cohesin

E. Cutts, S. Saravanan, G. Fisher, D. S. Rueda, L. Aragon

This study investigates how TOP2 resolves DNA braids and shows cohesin inhibits its activity by preventing substrate access.

bioRxiv · Nov 20, 2023Biophysics

Condensin compacts DNA in 15 nm steps and requires FACT for extrusion on chromatin

S. Sudhakar, G. L. Fisher, P. G. Escribano, J. G. Luis, E. Cutts, C. Cawood, L. Aragon, D. S. Rueda

The paper was withdrawn due to issues with two figures, and the authors do not wish it to be cited.

bioRxiv · Sep 15, 2021 · PreprintBiophysics

The contribution of cohesin to chromatid organisation is critical during chromosome segregation

J. Garcia-Luis, H. Bordelet, A. Thierry, R. Koszul, L. Aragon

The paper shows cohesin maintains chromatid organisation during anaphase in yeast, despite being thought to be removed by separase cleavage.

bioRxiv · Aug 27, 2021Cell Biology

A conserved activity for cohesin in bridging DNA molecules

P. Gutierrez-Escribano, M. Newton, A. Llauro, J. Huber, L. Tanasie, J. Davy, I. Aly, R. Aramayo, A. Montoya, H. Kramer, J. Stigler, D. Rueda, L. Aragon

This study identifies a conserved DNA bridging activity of cohesin complexes across species, revealing two bridge types with distinct force resistance and functional implications for cohesion and chromosome architecture.

bioRxiv · Sep 5, 2019 · PreprintBiochemistry