Biochemical Impact of p300-Mediated Acetylation of Replication Protein A: Implications for DNA Metabolic Pathway Choice
O. E. Ononye, S. Surendran, O. K. Howald, A. K. Petrides, M. R. Jordan, D. Ainembabazi, M. S. Wold, J. J. Turchi, L. Balakrishnan
This study shows that p300-mediated acetylation of RPA enhances its ssDNA binding affinity, particularly during G1/S phase and UV damage, influencing DNA metabolic pathway choice.
bioRxiv · Apr 22, 2024Biochemistry