Author

J. J. Turchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

K. S. Pawelczak· 3 shared P. S. VanderVere-Carozza· 3 shared N. S. Gavande· 2 shared A. H. Farmer· 1 shared A. H. Ghobashi· 1 shared C. R. Sears· 1 shared E. Ekinci· 1 shared H. M. O'Hagan· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

K. S. Pawelczak

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chemical exhaustion of RPA in cancer treatment

P. S. VanderVere-Carozza, K. S. Pawelczak, N. S. Gavande, S. I. Jalal, K. E. Pollok, E. Ekinci, J. Heyza, S. M. Patrick, J. J. Turchi

This paper develops RPA inhibitors that induce RPA exhaustion, showing anticancer activity in vitro and in vivo, and identifies RPA expression as a prognostic and predictive biomarker.

bioRxiv · Nov 30, 2020 · PreprintCancer Biology

Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A is Mediated by Replication Protein A in Ovarian Cancer

S. Sriramkumar, T. D. Matthews, A. H. Ghobashi, S. A. Miller, P. S. VanderVere-Carozza, K. S. Pawelczak, K. P. Nephew, J. J. Turchi, H. M. O'Hagan

This study identifies RING1A-mediated ubiquitination of phosphorylated H2AX at platinum DNA damage sites in ovarian cancer, revealing its role in DNA repair and platinum resistance.

Molecular Cancer Research · Nov 1, 2020Peer-reviewedCancer Biology

Discovery and Development of Novel DNA-PK Inhibitors by Targeting the unique Ku-DNA Interaction

N. S. Gavande, P. S. VanderVere-Carozza, K. S. Pawelczak, T. L. Vernon, L. A. Hanakahi, M. Summerlin, J. R. Dynlacht, A. H. Farmer, C. R. Sears, N. Al Nasrallah, J. Garrett, J. J. Turchi

This study discovers and develops a new class of DNA-PK inhibitors that target the Ku-DNA interaction, enhancing the efficacy of ionizing radiation and gene editing.

bioRxiv · Aug 24, 2020Biochemistry