Super-enhancer impairment is a link between MLL4 inactivated lung tumors and their vulnerability to glycolysis pathway inhibition
H. Alam, M. Tang, M. Maitituoheti, S. S. Dhar, S. Amin, B. Gu, T.-Y. Chen, Y.-H. Lin, J. Chen, F. Muller, F. J. DeMayo, L. Baseler, K. Rai, M. Lee
The paper shows that MLL4 loss in lung cancer promotes glycolysis and that inhibiting glycolysis selectively targets MLL4-mutant lung tumors.
bioRxiv · Dec 28, 2018 · PreprintCancer Biology