Y.-H. Lin

Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels

This study investigates how different crosslinker architectures affect the viscoelastic properties of dynamic covalent hydrogels, showing that side-chain and telechelic crosslinkers lead to distinct mechanical behaviors.

Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

A cyclic dipeptide for salinity stress alleviation and the trophic flexibility of an endophyte reveal niches in salt marsh plant-microbe interactions

This study identifies a cyclic dipeptide from an endophytic bacterium that alleviates salinity stress in plants, revealing insights into plant-microbe interactions in salt marshes.

Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis

This study identifies the STAT3/AMPK/PFKL axis in liver cancer, showing how it promotes glycolysis and tumor growth through stabilization of PFKL and RPIA in glycolytic bodies.

Expansion microscopy for super-resolution imaging of collagen-abundant tissues

This paper introduces ColExM, a method for expanding collagen-abundant tissues to enable super-resolution imaging of nanoscale structures.

Dietary bacteria control C. elegans fat content through pathways converging at phosphatidylcholine

This study identifies how dietary vitamin B12 influences phosphatidylcholine metabolism in C. elegans, affecting fat content through pathways involving SAM, PC, and regulatory proteins.

Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis

This study establishes a patient-derived HER2+ brain metastasis model and identifies Poziotinib as an effective RTKi for treating HER2+ breast cancer brain metastasis in mice.

Exogenous Methylglyoxal Improves Maize Yield by Alleviating Plant Diabetes and leaf senescence under Drought

This study shows exogenous methylglyoxal alleviates drought-induced leaf senescence and yield loss in maize by improving sugar metabolism and activating defense pathways.

Rapid assessment of changes in phage bioactivity using dynamic light scattering

This paper uses Dynamic Light Scattering to assess phage bioactivity changes over time and optimize storage conditions for clinical phage applications.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

High-Dimensional Spectral Cytometry Reveals Therapeutically Relevant Immune Subtypes in Gastric Cancer

This study uses high-dimensional spectral cytometry to identify immune subtypes in gastric cancer, finding that certain subtypes correlate with better responses to immunotherapy.

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

NAD+ biosynthesis as a collateral lethality target for precision oncology

The paper identifies NMNAT2 as a collateral lethality target in cancers with NMNAT1 deletions, showing selective toxicity in vitro and tumor eradication in vivo.

A multiomics analysis of direct interkingdom dynamics between influenza A virus and Streptococcus pneumoniae uncovers host-independent changes to bacterial virulence fitness

This study shows influenza A virus directly alters Streptococcus pneumoniae's virulence and metabolism without host involvement, revealing inter-kingdom interactions that enhance bacterial pathogenicity.

Maize AFP1 confers antifungal activity by inhibiting chitin deacetylases from a broad range of fungi

This study identifies maize AFP1 as an antifungal protein that inhibits chitin deacetylases in fungi by binding to mannosylated chitin, reducing fungal viability.

An all-solid-state heterojunction oxide transistor for the rapid detection of biomolecules and SARS-CoV-2 spike S1 protein

This paper develops an all-solid-state heterojunction oxide transistor for rapid, real-time detection of biomolecules and SARS-CoV-2 spike S1 protein at attomolar concentrations.

Degenerated virulence and irregular development of Fusarium oxysporum f. sp. niveum induced by successive subculture

This study shows that successive subculture of Fusarium oxysporum f. sp. niveum with aged mycelium leads to degeneration, reducing virulence through decreased cell wall-degrading enzyme activity and virulence gene expression.

Targeting host glycolysis as a strategy for antimalarial development.

The paper investigates enolase inhibitors' effects on erythrocytes and their implications for antimalarial therapy by examining red blood cell homeostasis and parasite growth.

The global proteome and phosphoproteome landscape of sepsis-induced kidney injury

This study identifies 2,119 proteins and 2,950 phosphosites in sepsis-induced kidney injury, revealing pathways related to metabolism, oxidative stress, and energy consumption during transition to chronic kidney disease.

Netome: The Molecular Characterization of Neutrophil Extracellular Traps (NETs)

This study characterizes the molecular composition of neutrophil extracellular traps (NETs) using omics approaches, revealing specific genomic and proteomic signatures.

Maturation of human induced pluripotent stem cell-derived cardiomyocytes for modeling hypertrophic cardiomyopathy

This study develops a method to mature hiPSC-CMs, enabling them to model adult-onset cardiovascular disease like hypertrophic cardiomyopathy.

Methylthioadenosine is Not Dramatically Elevated in MTAP-Homozygous Deleted Primary Glioblastomas

This paper shows that MTA levels are not significantly elevated in MTAP-homozygous deleted primary human glioblastomas, challenging the clinical relevance of targeting PRMT5 and MAT2A in these tumors.

Nutritional Immunity and Antibiotic Drug Treatments Influence Microbial Composition but Fail to Eliminate Urethral Catheter Biofilms in Recurrently Catheterized Patients

The study examines microbial dynamics and host interactions in urethral catheter biofilms, showing antibiotic treatments alter composition but fail to eliminate biofilms.

Super-enhancer impairment is a link between MLL4 inactivated lung tumors and their vulnerability to glycolysis pathway inhibition

The paper shows that MLL4 loss in lung cancer promotes glycolysis and that inhibiting glycolysis selectively targets MLL4-mutant lung tumors.

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

A Chemically-triggered Transition from Conflict to Cooperation in Burying Beetles

This study shows that interspecific competition with blowflies triggers cooperation in burying beetles through a chemical cue, dimethyl disulfide.