K. Rai

Multiplexed fluorescence and scatter detection with single cell resolution using on-chip fiber optics for droplet microfluidic applications

The paper introduces OptiDrop, a platform that enables multi-parametric optical sensing of microfluidic droplets with single-cell resolution using on-chip fiber optics.

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

The Androgen Receptor: A Therapeutic Target in Desmoplastic Small Round Cell Sarcoma

The paper shows that DSRCT is driven by the androgen receptor and responds to androgen deprivation therapy.

KMT2D Loss Promotes Head and Neck Squamous Cell Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment

This study shows KMT2D loss in HNSCC leads to enhancer reprogramming and immune microenvironment changes, promoting tumor growth through interferon signaling disruption.

High Enhancer Activity is an Epigenetic Feature of HPV Negative Atypical Head and Neck Squamous Cell Carcinoma

The paper identifies high enhancer activity in HPV-negative atypical HNSCC as linked to BET inhibitor resistance and upregulated signaling pathways.

H3K4me1-marked Enhancer Activation in Resistant Prostate Cancers Implicates SOX4 and MENIN Inhibition as Therapeutic Strategies

The paper identifies H3K4me1-marked enhancers in therapy-resistant prostate cancers and suggests SOX4 and MENIN inhibition as therapeutic strategies.

New cellular models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor

This study generates new cell lines for undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor to better study sarcomagenesis and develop therapies.

Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal Cancer

This study identifies enhancer subtypes in colorectal cancer through epigenomic analysis and proposes targeted therapeutic strategies based on these subtypes.

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

Immune landscape of a genetically-engineered murine model of glioma relative to human glioma by single-cell sequencing

This study compares the immune landscape of a genetically-engineered murine glioma model to human glioma using single-cell sequencing, finding similar immunosuppressive features but differences in immune cell composition between mouse models and human samples.

Genomes of intracellular Leishmania parasites directly sequenced from patients

This paper develops a method to directly sequence Leishmania genomes from clinical samples, revealing genomic differences between intracellular parasites and cultured isolates.

Bivalent and Broad Chromatin Domains Regulate Pro-metastatic Drivers in Melanoma

The paper identifies bivalent chromatin states and broad H3K4me3 domains associated with pro-metastatic drivers in melanoma using ChIP-sequencing data from tumor samples and cell lines.

Super-enhancer impairment is a link between MLL4 inactivated lung tumors and their vulnerability to glycolysis pathway inhibition

The paper shows that MLL4 loss in lung cancer promotes glycolysis and that inhibiting glycolysis selectively targets MLL4-mutant lung tumors.

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.