The roseoloviruses downregulate the protein tyrosine phosphatase PTPRC(CD45)
M. L. Whyte, K. A. Smith, A. Buchberger, L. Berg Luecke, L. Handayani Tjan, Y. Mori, R. Gundry, A. W. Hudson
This study identifies that HHV6A and HHV7 downregulate CD45 on T cells, impairing immune signaling and potentially promoting viral latency.
bioRxiv · Sep 29, 2020Microbiology