K. A. Smith

Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α

This study investigates the role of B55α in cardiac transcriptome regulation, finding sex-specific effects on cardiac fibrosis and gene expression.

Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands

The paper identifies epithelial IL-2 as critical for maintaining NK cell function in mammary glands, leading to improved immunosurveillance and prevention of tumor development.

Assessing a Role for Sarcospan in Immune Function

This study investigates the role of sarcospan in immune function by analyzing its expression in immune cells and assessing its impact on B cell development and effector functions in SSPN-deficient mice.

Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress

The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.

The roseoloviruses downregulate the protein tyrosine phosphatase PTPRC(CD45)

This study identifies that HHV6A and HHV7 downregulate CD45 on T cells, impairing immune signaling and potentially promoting viral latency.

Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations

The paper uses biopsy data and a mechanistic model to study interactions between EGFR and PDGFRA amplified sub-populations in glioblastomas.