Cardiopulmonary bypass activates classical monocytes via shear-mediated activation of Store-Operated Calcium Entry
W. Li, L. N. Tu, L. Hsieh, J. R. Smith, Y.-T. Yeh, A. Sinyagin, M. Ghassemian, A. Timms, K. Charette, D. Mauchley, M. McMullan, L. Bohuta, C. Greene, M. Regier, J. C. del Alamo, , V. Nigam
The paper identifies SPTAN1 and RAF1 as genes activated by shear stress during cardiopulmonary bypass, leading to inflammation and cell death through store-operated calcium entry.
bioRxiv · May 4, 2022 · PreprintCell Biology