M. Ghassemian

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

A transcriptionally active lipid vesicle encloses theinjected Chimalliviridae genome in early infection

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

Identification of the bacteriophage nucleus protein interaction network

The paper identifies proteins interacting with the phage nucleus protein ChmA and describes their potential roles in genome packaging and transport.

Phosphorylation of Gαi shapes canonical Gα(i)βγ/GPCR signaling

This study identifies phosphorylation sites on Gαi that modulate GPCR signaling by altering Gi activation and localization, revealing mechanisms of cross-talk between growth factor and chemokine signaling pathways.

Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.

This study shows that loss of obscurin and Obsl1 in mice causes diastolic dysfunction, altered metabolism, and deregulated mitophagy in the heart.

Cardiopulmonary bypass activates classical monocytes via shear-mediated activation of Store-Operated Calcium Entry

The paper identifies SPTAN1 and RAF1 as genes activated by shear stress during cardiopulmonary bypass, leading to inflammation and cell death through store-operated calcium entry.

Evolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates

The paper examines the evolutionary changes in GIV/Girdin's modularity, interactome, and functions across invertebrates and vertebrates, revealing distinct roles in cancer as tumor suppressor or oncogene.

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.

Tyrosine-based Signals Regulate the assembly of Daple-PARD3 Complex at Cell-cell Junctions during Polarized Planar Cell Migration

The paper shows that tyrosine phosphorylation regulates Daple-PARD3 complex assembly at cell-cell junctions, influencing planar cell polarity during migration.

Convergence of Wnt, Growth Factor and Trimeric G protein signals on Daple

This study identifies Daple as a convergence point for Wnt, growth factor, and G-protein signaling in cancer, showing its role in tumor progression and poor prognosis in colorectal cancer.