Author

L. Brown Swigart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. I. Evan· 2 shared L. Pellegrinet· 2 shared N. M. Sodir· 2 shared R. M. Kortlever· 2 shared T. D. Littlewood· 2 shared A. Perfetto· 1 shared D. Garcia· 1 shared L. Soucek· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

G. I. Evan

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 30, 2020

Preventing cancer by long-term partial Myc suppression

N. M. Sodir, L. Pellegrinet, R. M. Kortlever…·G. I. Evan

This study shows that acute Myc suppression in adult mice prevents KRasG12D-driven lung and pancreatic cancers with minimal side effects when applied metronomically.

DOI 10.1101/2020.12.30.422650

mouseexperimental assay

Cancer BiologybioRxivFeb 21, 2019

Myc instructs and maintains pancreatic adenocarcinoma phenotype

N. M. Sodir, R. M. Kortlever, V. J. Barthet…·G. I. Evan

This study shows Myc activation in PanIN cells drives the transition to PDAC by instructing a fibroinflammatory stroma, and its deactivation reverses the phenotype, suggesting Myc as a reversible molecular switch for PDAC.

DOI 10.1158/2159-8290.cd-19-0435

mouseexperimental assay