Author

G. I. Evan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

L. Brown Swigart· 2 shared L. Pellegrinet· 2 shared N. M. Sodir· 2 shared R. M. Kortlever· 2 shared T. D. Littlewood· 2 shared A. Perfetto· 1 shared D. Garcia· 1 shared L. Soucek· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

L. Brown Swigart

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2 papers

Recent·Most cited

Preventing cancer by long-term partial Myc suppression

N. M. Sodir, L. Pellegrinet, R. M. Kortlever, Y.-W. Kwon, S. Kim, D. Garcia, A. Perfetto, P. Anastasiou, L. Brown Swigart, T. D. Littlewood, G. I. Evan

This study shows that acute Myc suppression in adult mice prevents KRasG12D-driven lung and pancreatic cancers with minimal side effects when applied metronomically.

bioRxiv · Dec 30, 2020 · PreprintCancer Biology

Myc instructs and maintains pancreatic adenocarcinoma phenotype

N. M. Sodir, R. M. Kortlever, V. J. Barthet, L. Pellegrinet, T. Campos, S. Kupczak, L. Brown Swigart, L. Soucek, M. J. Arends, T. D. Littlewood, G. I. Evan

This study shows Myc activation in PanIN cells drives the transition to PDAC by instructing a fibroinflammatory stroma, and its deactivation reverses the phenotype, suggesting Myc as a reversible molecular switch for PDAC.

bioRxiv · Feb 21, 2019Cancer Biology