Author

L. Brueckner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Eggert· 2 shared K. Haase· 2 shared N. Wittstruck· 2 shared A. Bhattacharya· 1 shared A. G. Henssen· 1 shared A. Heeren-Hagemann· 1 shared A. Henssen· 1 shared A. Szymansky· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

A. Eggert

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2 papers

Recent·Most cited

Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversity

M. C. Stoeber, R. Chamorro Gonzalez, L. Brueckner, T. Conrad, N. Wittstruck, A. Szymansky, A. Eggert, J. H. Schulte, R. P. Koche, A. G. Henssen, R. F. Schwarz, K. Haase

The paper investigates how ecDNA copy number heterogeneity affects gene expression and transcriptional states in neuroblastoma cells using single-cell DNA and RNA sequencing.

bioRxiv · Jan 21, 2023Cancer Biology

Amplicon structure creates collateral therapeutic vulnerability in cancer

Y. Bei, L. Brame, M. Kirchner, R. Fritsche, S. Kunz, A. Bhattacharya, J. Koeppke, J. Proba, N. Wittstruck, O. Sidorova, R. Chamorro, H. Dorado Garcia, L. Brueckner, R. Xu, M. Giurgiu, , A. Henssen

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

bioRxiv · Sep 8, 2022 · PreprintCancer Biology