Author

L. C. Fernandez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:protein structure· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

E. Biasini· 3 shared G. Spagnolli· 3 shared J. R. Requena· 3 shared A. Iglesias· 2 shared H. Erana· 2 shared J. Castilla· 2 shared M. Martin-Pastor· 2 shared R. Lopez-Moreno· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

E. Biasini

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Solid state NMR reveals a parallel in register architecture for an infectious recombinant prion

M. Martin-Pastor, Y. B. Codeseira, G. Spagnolli, H. Erana, L. C. Fernandez, D. Martin, S. Bravo, N. Lopez-Lorenzo, A. Iglesias, R. Lopez-Moreno, R. Sabate, S. Veiga, H. Rezaei, E. Biasini, V. M. Sanchez-Pedregal, , J. R. Requena

The paper uses solid state NMR to analyze the structure of infectious recombinant prion, finding support for the parallel in register beta stack model over the 4-rung beta-solenoid model.

bioRxiv · Jul 20, 2021 · PreprintBiochemistry

Structural features of an infectious recombinant PrPSc prion using solid state NMR

M. Martin-Pastor, Y. B. Codeseira, G. Spagnolli, H. Erana, L. C. Fernandez, S. Bravo, A. Iglesias, R. Lopez-Moreno, S. Veiga, E. Biasini, V. M. Sanchez-Pedregal, J. Castilla, J. R. Requena

This study uses solid-state NMR to analyze the structure of a recombinant PrPSc prion and validates a proposed atomistic model of its beta-solenoid structure.

bioRxiv · Apr 8, 2020 · PreprintBiochemistry

PHARMACOLOGICAL PROTEIN INACTIVATION BY TARGETING FOLDING INTERMEDIATES

G. Spagnolli, T. Massignan, A. Astolfi, S. Biggi, P. Brunelli, M. Libergoli, A. Ianeselli, S. Orioli, A. Boldrini, L. Terruzzi, G. Maietta, M. Rigoli, N. Lopez Lorenzo, L. C. Fernandez, L. Tosatto, , E. Biasini

The paper discovers non-native metastable states in protein folding pathways and develops a novel drug discovery approach, PPI-FIT, to target these intermediates to lower protein expression.

bioRxiv · Mar 31, 2020 · PreprintBiochemistry