Regulation of fatty acid delivery to metastases by tumor endothelium
D. N. Edwards, S. Wang, W. Song, L. C. Kim, V. M. Ngwa, Y. Hwang, K. C. Ess, M. R. Boothby, J. Chen
This study identifies a mechanism by which tumor endothelium regulates fatty acid delivery to metastases, showing that mTORC1 inhibition in endothelial cells reduces metastatic disease by impairing T cell fatty acid uptake.
bioRxiv · Apr 2, 2024 · PreprintCancer Biology