M. R. Boothby

Regulation of fatty acid delivery to metastases by tumor endothelium

This study identifies a mechanism by which tumor endothelium regulates fatty acid delivery to metastases, showing that mTORC1 inhibition in endothelial cells reduces metastatic disease by impairing T cell fatty acid uptake.

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.

Plasma cell differentiation, antibody quality, and initial germinal center B cell population depend on glucose influx rate

This study shows that glucose influx is critical for germinal center function and plasma cell production, but plasma cells can also use alternative hexose sugars for antibody secretion.

CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth

This study shows that CXCR2 expression in melanoma progenitor cells drives tumor growth by altering transcriptional programs and immune responses.

Selective pharmaceutical inhibition of PARP14 mitigates allergen-induced IgE and mucus overproduction in a mouse model of pulmonary allergic response

This study shows that inhibiting PARP14's catalytic activity reduces allergen-induced IgE and mucus overproduction in a mouse model of allergic response.

Generalizing about GC (hypoxia): Dys- & Dat-InformaticaComment on Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

The paper re-analyzes genomics data to address discrepancies in conclusions about hypoxia's role in germinal center B cells and advocates for transparent reporting of new data relative to existing cell type fingerprints.