Integrated Proteogenomic Deep Sequencing and Analytics Accurately Identify Non-Canonical Peptides in Tumor Immunopeptidomes
C. Chong, M. Muller, H. Pak, D. Harnett, F. Huber, D. Grun, M. Leleu, A. Auger, M. Arnaud, B. J. Stevenson, J. Michaux, I. Bilic, A. Hirsekorn, L. Calviello, L. Simo-Riudalbas, , M. Bassani-Sternberg
The paper develops an MS-based proteogenomic approach to identify non-canonical HLA peptides in tumors, finding hundreds of shared and tumor-specific peptides, including an immunogenic one from ABCB5.
bioRxiv · Sep 6, 2019Cancer Biology