D. Trono

The human-restricted oncoprotein POU5F1B enhances cell invasiveness through plasma membrane remodeling

This study identifies POU5F1B as a human-specific oncoprotein that enhances cell invasiveness via plasma membrane remodeling through ubiquitination and S-acylation.

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

SARS-CoV-2 shifts transcription of host gene to increase Spike acylation and boost infectivity

This study shows SARS-CoV-2 infection alters zddhc20 transcription, producing a longer ZDHHC20 protein that enhances Spike acylation and viral infectivity.

KRAB zinc finger proteins ZNF587/ZNF417 protect lymphoma cells from replicative stress-induced inflammation

This study identifies ZNF587 and ZNF417 as pro-oncogenic factors in DLBCL that reduce replicative stress and inflammation, promoting cancer cell survival and immune evasion.

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

The paper reports cryo-EM structures of mouse ACE2 bound to SARS-CoV-2 VOC Spike proteins, showing mutations enabling immune escape may expand host range.

P2G3 human monoclonal antibody neutralizes SARS-CoV-2 Omicron subvariants including BA.4 and BA.5 and Bebtelovimab escape mutants

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties

This paper identifies a potent human monoclonal antibody, P2G3, that neutralizes multiple SARS-CoV-2 variants including Omicron, and demonstrates its protective efficacy in a monkey model.

Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion.

The paper reports cryo-EM structures of mouse ACE2 bound to Spike proteins of four SARS-CoV-2 variants, revealing mutations that enhance binding and immune evasion.

Primate-specific cis- and trans-regulators shape transcriptional networks during human development

The paper identifies primate-specific transposable elements and their regulatory factors that influence transcriptional networks during human development.

S-acylation controls SARS-Cov-2 membrane lipid organization and enhances infectivity

The paper shows that S-acylation by ZDHHC20 modifies SARS-CoV-2 membrane proteins, promoting lipid domain formation and enhancing viral infectivity.

Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression

The paper shows HERV activation in tumors upregulates KZFPs, which suppress cancer progression by downregulating cell cycle and adhesion genes, improving disease outcomes.

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

The paper identifies primate-specific KZFPs that repress retrotransposons in human neurons, influencing differentiation and preventing neurotoxic responses.

Integrated Proteogenomic Deep Sequencing and Analytics Accurately Identify Non-Canonical Peptides in Tumor Immunopeptidomes

The paper develops an MS-based proteogenomic approach to identify non-canonical HLA peptides in tumors, finding hundreds of shared and tumor-specific peptides, including an immunogenic one from ABCB5.

KAP1 is an antiparallel dimer with a natively functional asymmetry

This paper shows KAP1 forms an antiparallel dimer with a native asymmetry, which affects its SUMOylation and interaction with HP1.