Author

L. Curtin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Approach:mechanistic / dynamical model· 2

Frequent Co-Authors

K. R. Swanson· 6 shared A. Hawkins-Daarud· 5 shared M. R. Owen· 4 shared K. G. van der Zee· 3 shared L. S. Hu· 3 shared A. B. Porter· 2 shared B. R. Bendok· 2 shared G. De Leon· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersCancer Biology

K. R. Swanson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mapping multiregional imaging-localized biopsies to MRI habitats reveals biologically significant glioma tissue states and associated patterns of cohabitating cellular subpopulations

L. Curtin, K. M. Bond, P. R. Jackson, A. Hawkins-Daarud, S. Velez, N. Shakir, J. C. Urcuyo, G. De Leon, K. W. Singleton, J. M. Langworthy, K. Clark-Swanson, Y. Lassiter-Morris, L. Paulson, C. Sereduk, C. Krishna, , K. R. Swanson

The paper maps MRI-localized glioma biopsies to MRI habitats, identifying transcriptional tissue states and their association with cellular subpopulations and MRI features.

bioRxiv · Mar 23, 2022 · PreprintCancer Biology

Partial loss of succinate dehydrogenase reduces high red cell distribution width and promotes healthy survival in chronically hypoxic mice

B. E. Baysal, D. Tabaczynski, L. Curtin, M. Seshadri, S. Sexton

bioRxiv · May 18, 2021 · PreprintPhysiology

A Mechanistic Investigation into Ischemia-Driven Distal Recurrence of Glioblastoma

L. Curtin, A. Hawkins-Daarud, A. B. Porter, K. G. van der Zee, M. R. Owen, K. R. Swanson

This study extends a GBM mechanistic model to investigate how ischemia influences distal tumor recurrence by incorporating vascular efficiency and hypoxia.

Bulletin of Mathematical Biology · Nov 7, 2020Peer-reviewedCancer Biology

Modeling the Role of Hypoxia in Glioblastoma Growth and Recurrence Patterns

L. Curtin, A. Hawkins-Daarud, A. B. Porter, M. R. Owen, K. G. van der Zee, K. R. Swanson

This study uses a computational model to show that hypoxic cell migration drives glioblastoma growth and distant recurrence.

bioRxiv · Aug 22, 2020 · PreprintCancer Biology

Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations

B. Morris, L. Curtin, A. Hawkins-Daarud, M. E. Hubbard, R. Rahman, S. J. Smith, D. Auer, N. L. Tran, L. S. Hu, J. M. Eschbacher, K. A. Smith, A. Stokes, K. R. Swanson, M. R. Owen

The paper uses biopsy data and a mechanistic model to study interactions between EGFR and PDGFRA amplified sub-populations in glioblastomas.

bioRxiv · Apr 8, 2020Cancer Biology

Investigating the Role of Hypoxia-Induced Migration in Glioblastoma Growth Rates

L. Curtin, A. Hawkins Daarud, K. G. van der Zee, K. R. Swanson, M. R. Owen

The paper extends the PIHNA model to study how hypoxic and normoxic cell migration rates affect glioblastoma growth wave-speed, identifying a minimum wave-speed and conditions for increased growth.

bioRxiv · Dec 5, 2019Cancer Biology

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

P. Whitmire, C. R. Rickertsen, A. Hawkins-Daarud, E. Carrasco, J. Lorence, G. De Leon, L. Curtin, S. Bayless, K. Clark-Swanson, N. C. Peeri, C. Corpuz, C. P. Lewis-de los Angeles, B. R. Bendok, L. Gonzalez-Cuyar, S. Vora, , K. R. Swanson

This study identifies sex-specific predictors of survival in glioblastoma patients using MR imaging and clinical data.

bioRxiv · Sep 25, 2018Cancer Biology