RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention
P. M. dos Passos, E. H. Hemamali, L. D. Mamede, L. R. Hayes, Y. M. Ayala
This study shows that RNA-mediated TDP-43 self-assembly forms macromolecular complexes that retain TDP-43 in the nucleus, preventing cytoplasmic aggregation and highlighting potential therapeutic targets.
bioRxiv · Aug 6, 2023Cell Biology