Author

P. M. dos Passos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:protein structure· 1

Frequent Co-Authors

Y. M. Ayala· 2 shared A. A. Hyman· 1 shared A. Honigmann· 1 shared A. Rizuan· 1 shared A. Sergeeva· 1 shared D. Kuster· 1 shared E. H. Hemamali· 1 shared H. L. Danielson· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Y. M. Ayala

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Author profile →

2 papers

Recent·Most cited

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

X. Yan, D. Kuster, P. Mohanty, J. Nijssen, K. Pombo-Garcia, A. Rizuan, T. M. Franzmann, A. Sergeeva, P. M. dos Passos, L. George, S.-H. Wang, J. Shenoy, H. L. Danielson, A. Honigmann, Y. M. Ayala, , A. A. Hyman

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

bioRxiv · Jan 23, 2024Cell Biology

RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention

P. M. dos Passos, E. H. Hemamali, L. D. Mamede, L. R. Hayes, Y. M. Ayala

This study shows that RNA-mediated TDP-43 self-assembly forms macromolecular complexes that retain TDP-43 in the nucleus, preventing cytoplasmic aggregation and highlighting potential therapeutic targets.

bioRxiv · Aug 6, 2023Cell Biology