Leveraging Fungal Calcineurin-Inhibitor Structures, Biophysics and Dynamics to Design Selective and Non-Immunosuppressive FK506 Analogs
S. M.- C. Gobeil, B. G. Bobay, P. R. Juvvadi, C. D. Cole, J. Heitman, W. J. Steinbach, R. A. Venters, L. D. Spicer
The paper designs fungal-selective FK506 analogs by analyzing structural and biophysical differences between human and fungal FKBP12 proteins.
bioRxiv · Apr 14, 2020Biochemistry