Author

P. R. Juvvadi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Approach:deep learning· 1 Organism:fungi (other)· 1 Organism:human· 1

Frequent Co-Authors

J. Heitman· 3 shared B. G. Bobay· 2 shared E. Park· 2 shared J. Hong· 2 shared M. Ciofani· 2 shared M. J. Hoy· 2 shared W. J. Steinbach· 2 shared A. Floyd Averette· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMicrobiology

J. Heitman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivJun 5, 2023

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans

A. Rivera, W. Lim, E. Park…·J. Heitman

This paper identifies a modified FK520 analog, JH-FK-08, with reduced immunosuppression and improved antifungal efficacy against C. neoformans in vivo.

DOI 10.1128/mbio.01810-23

C. elegansexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivMar 25, 2022

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

M. J. Hoy, E. Park, H. Lee…·J. Heitman

This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.

DOI 10.1128/mbio.01049-22

mouseexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivApr 14, 2020

Leveraging Fungal Calcineurin-Inhibitor Structures, Biophysics and Dynamics to Design Selective and Non-Immunosuppressive FK506 Analogs

S. M.- C. Gobeil, B. G. Bobay, P. R. Juvvadi…·L. D. Spicer

The paper designs fungal-selective FK506 analogs by analyzing structural and biophysical differences between human and fungal FKBP12 proteins.

DOI 10.1128/mbio.03000-21

humanmouse

𝕏 PostBluesky