Author

W. J. Steinbach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:fungi (other)· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. Heitman· 2 shared P. R. Juvvadi· 2 shared A. Floyd Averette· 1 shared A. Rivera· 1 shared B. G. Bobay· 1 shared C. D. Cole· 1 shared E. Park· 1 shared I. Spasojevic· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

J. Heitman

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans

A. Rivera, W. Lim, E. Park, P. A. Dome, M. J. Hoy, I. Spasojevic, S. Sun, A. Floyd Averette, S. Pina-Oviedo, P. R. Juvvadi, W. J. Steinbach, M. Ciofani, J. Hong, J. Heitman

This paper identifies a modified FK520 analog, JH-FK-08, with reduced immunosuppression and improved antifungal efficacy against C. neoformans in vivo.

bioRxiv · Jun 5, 2023Microbiology

Leveraging Fungal Calcineurin-Inhibitor Structures, Biophysics and Dynamics to Design Selective and Non-Immunosuppressive FK506 Analogs

S. M.- C. Gobeil, B. G. Bobay, P. R. Juvvadi, C. D. Cole, J. Heitman, W. J. Steinbach, R. A. Venters, L. D. Spicer

The paper designs fungal-selective FK506 analogs by analyzing structural and biophysical differences between human and fungal FKBP12 proteins.

bioRxiv · Apr 14, 2020Biochemistry