Author

B. G. Bobay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:fungi (other)· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. Heitman· 2 shared P. R. Juvvadi· 2 shared C. D. Cole· 1 shared D. C. Cole· 1 shared D. Fox· 1 shared E. Park· 1 shared H. Lee· 1 shared J. Hong· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

J. Heitman

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Author profile →

2 papers

Recent·Most cited

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

M. J. Hoy, E. Park, H. Lee, W. Y. Lim, D. C. Cole, N. D. DeBouver, B. G. Bobay, P. G. Pierce, D. Fox, M. Ciofani, P. R. Juvvadi, W. Steinbach, J. Hong, J. Heitman

This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.

bioRxiv · Mar 25, 2022Microbiology

Leveraging Fungal Calcineurin-Inhibitor Structures, Biophysics and Dynamics to Design Selective and Non-Immunosuppressive FK506 Analogs

S. M.- C. Gobeil, B. G. Bobay, P. R. Juvvadi, C. D. Cole, J. Heitman, W. J. Steinbach, R. A. Venters, L. D. Spicer

The paper designs fungal-selective FK506 analogs by analyzing structural and biophysical differences between human and fungal FKBP12 proteins.

bioRxiv · Apr 14, 2020Biochemistry