CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis
G. J. Randolph, A. Elvington, O. Baba, D. Sultan, G. S. Heo, X. Zhang, H. Luehmann, L. Detering, M. Szpakowska, A. Chevigne, Y. Liu
This study shows that a CXCR4-binding PET tracer accumulates in atherosclerotic plaques due to endothelial CXCR4 expression, linking endothelial injury to monocyte recruitment.
bioRxiv · Jan 2, 2020Pathology