G. S. Heo

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

Ketosis Prevents Abdominal Aortic Aneurysm Rupture Through CCR2 Downregulation and Enhanced MMP Balance

This study shows that ketosis reduces AAA expansion and rupture by downregulating CCR2 and improving MMP balance in rat models.

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

Reprogramming Alveolar Macrophage Responses to TGF-β Reveals CCR2+ Monocyte Activity that Promotes Bronchiolitis Obliterans Syndrome

This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.

Chemokine receptor 2-targeted molecular imaging in pulmonary fibrosis

PET imaging of CCR2+ cells in lung fibrosis identifies therapeutic response in mouse models and shows perifibrotic signal in IPF patients.

CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis

This study shows that a CXCR4-binding PET tracer accumulates in atherosclerotic plaques due to endothelial CXCR4 expression, linking endothelial injury to monocyte recruitment.