Author

G. J. Randolph

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. S. Czepielewski· 3 shared E. J. Onufer· 2 shared K. Kim· 2 shared A. Alarcon de la Lastra· 1 shared A. Cerutti· 1 shared A. Chevigne· 1 shared A. D. Polydorides· 1 shared A. Dunn· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

R. S. Czepielewski

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

P. Canales-Herrerias, M. Uzzan, A. Seki, R. S. Czepielewski, B. Verstockt, A. Livanos, F. Raso, A. Dunn, D. Dai, A. Wang, Z. Al-taie, J. Martin, H. M. Ko, M. Tokuyama, M. Tankelevich, , S. Mehandru

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

bioRxiv · Jan 19, 2023Immunology

Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

J. M. Baer, C. Zuo, L.-I. Kang, A. Alarcon de la Lastra, N. C. Borcherding, B. L. Knolhoff, S. J. Bogner, Y. Zhu, M. A. Lewis, N. Zhang, K.-w. Kim, R. C. Fields, J. C. Mills, L. Ding, G. J. Randolph, D. G. DeNardo

This study shows that pancreas resident macrophages (TRMs) have distinct roles in pancreatitis and pancreatic cancer, promoting fibrosis in inflammation but driving cancer progression.

bioRxiv · Feb 9, 2022 · PreprintImmunology

Intestinal epithelium-derived high density lipoprotein restrains liver injury via the portal vein

Y.-H. Han, E. J. Onufer, L. H. Huang, R. S. Czepielewski, B. W. Warner, G. J. Randolph

This study shows intestinal HDL neutralizes LPS in the portal vein, protecting the liver from injury in a mouse model of short bowel syndrome.

bioRxiv · Oct 1, 2020 · PreprintImmunology

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

A. Gainullina, L.-H. Huang, H. Todorov, K. Kim, L. S. Yng, A. Kent, B. Jia, K. Seddu, K. Krchma, J. Wu, K. Crozat, E. Tomasello, V. Narang, R. Dress, P. See, , ImmGen Consortium

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

bioRxiv · Jul 15, 2020Immunology

CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis

G. J. Randolph, A. Elvington, O. Baba, D. Sultan, G. S. Heo, X. Zhang, H. Luehmann, L. Detering, M. Szpakowska, A. Chevigne, Y. Liu

This study shows that a CXCR4-binding PET tracer accumulates in atherosclerotic plaques due to endothelial CXCR4 expression, linking endothelial injury to monocyte recruitment.

bioRxiv · Jan 2, 2020Pathology

Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programming

P. L. Wang, A. K. Yim, K. Kim, D. Avey, R. S. Czepielewski, M. Colonna, J. Milbrandt, G. J. Randolph

This study identifies shared and unique features between peripheral nerve macrophages and CNS microglia, showing PNS macrophages express genes associated with microglial activation.

bioRxiv · Dec 19, 2019 · PreprintImmunology