Pathogenic, but not non-pathogenic, Rickettsia evade inflammasome-dependent IL-1 responses to establish an intracytosolic replication niche.
O. H. Voss, J. Cobb, H. Gaytan, N. Rivera Diaz, R. Sanchez, L. DeTolla, M. S. Rahman, A. F. Azad
This study shows pathogenic Rickettsia species evade IL-1 responses via Caspase-11-Gsdmd pathway to replicate intracellularly, unlike non-pathogenic Rickettsia.
bioRxiv · Sep 8, 2021 · PreprintMicrobiology