H. Gaytan

Pathogenic Rickettsia species evade autophagosomal maturation and reduce anti-microbicidal pro-inflammatory IL-1 responses to support their intracellular survival.

This study identifies a mechanism by which pathogenic Rickettsia species evade autophagosomal maturation and reduce IL-1 responses to survive in macrophages.

Pathogenic, but not non-pathogenic, Rickettsia evade inflammasome-dependent IL-1 responses to establish an intracytosolic replication niche.

This study shows pathogenic Rickettsia species evade IL-1 responses via Caspase-11-Gsdmd pathway to replicate intracellularly, unlike non-pathogenic Rickettsia.