R. Sanchez

Comprehensive Landscape of Non-muscle Invasive Bladder Cancer Tumour Microenvironment and Prognostic value of Cancer-Associated Myofibroblasts

The paper analyzes the tumor microenvironment of NMIBC, finding that cancer-associated myofibroblasts are prognostic markers for progression and recurrence.

Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1

The paper characterizes the human LOR domain of AASS, presents its crystal structure, and identifies it as a potential drug target for glutaric aciduria type 1.

The sunflower WRINKLED1 transcription factor regulates fatty acid biosynthesis genes through an AW box binding sequence with a particular base bias

Pathogenic, but not non-pathogenic, Rickettsia evade inflammasome-dependent IL-1 responses to establish an intracytosolic replication niche.

This study shows pathogenic Rickettsia species evade IL-1 responses via Caspase-11-Gsdmd pathway to replicate intracellularly, unlike non-pathogenic Rickettsia.

A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy

This study identifies a novel NR2F1 agonist, C26, that suppresses metastasis by inducing cancer cell dormancy through NR2F1 activation in HNSCC.

Subnanometer-resolution structure determination in situ by a hybrid subtomogram averaging - single particle cryoEM - workflow

The paper introduces a hybrid workflow combining subtomogram averaging and single-particle cryoEM to improve resolution in structural determination, achieving subnanometer resolution for tobacco mosaic virus and RyR1 ion channel.

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

This study identifies DHTKD1 inhibitors and reports its crystal structure with thiamin diphosphate, revealing how mutations affect its function and stability.

Integrative Network Analysis of Differentially Methylated and Expressed Genes for Biomarker Identification in Leukemia

The paper integrates DNA methylation and gene expression data to identify biomarkers in leukemia by analyzing shared pathways and gene hubs.

DHTKD1 and OGDH display in vivo substrate overlap and form a hybrid ketoacid dehydrogenase complex

The paper shows DHTKD1 and OGDH share in vivo substrate overlap and form a hybrid ketoacid dehydrogenase complex, with implications for GA1 therapy.

Measurement of ocular transmission in living human eyes with a double-pass system

The paper develops a noninvasive method to measure ocular transmission in living human eyes using a double-pass system at 780 nm, finding linear relationships between laser voltage and transmittance.

The deadly touch: protein denaturation at the water-air interface and how to prevent it

The paper investigates protein denaturation at the air-water interface using electron cryo-microscopy and shows that hydrophilized graphene prevents this denaturation.

An epigenetic breeding system in soybean for increased yield and stability

This study uses an epigenetic breeding system in soybean to increase yield and stability by inducing epigenetic variation through MSH1 suppression.