Author

L. E. Donnelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 2

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. R. Baker· 2 shared P. J. Barnes· 2 shared P. S. Fenwick· 2 shared C. K. Coss· 1 shared H. B. Owles· 1 shared J. Fine· 1 shared J. V. Devulder· 1 shared K. C. El-Kasmi· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

J. R. Baker

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2 papers

Recent·Most cited

Extracellular vesicles propagate aging in COPD airway epithelial cells by transfer of microRNA-34a

J. V. Devulder, J. R. Baker, P. S. Fenwick, L. Odqvist, L. E. Donnelly, P. J. Barnes

This study shows that extracellular vesicles from COPD airway cells transfer miR-34a to healthy cells, inducing senescence by reducing SIRT1 and increasing p21CIP1.

bioRxiv · Dec 18, 2023 · PreprintCell Biology

Imbalance between IL-36 receptor agonist and antagonist drives neutrophilic inflammation in COPD

J. R. Baker, P. S. Fenwick, C. K. Coss, H. B. Owles, S. L. Elkin, M. Thomas, J. Fine, K. C. El-Kasmi, P. J. Barnes, L. E. Donnelly

The paper identifies an imbalance between IL-36 receptor agonist and antagonist in COPD patients, showing it drives neutrophilic inflammation and suggests a therapeutic antibody targeting IL-36R as a potential treatment.

bioRxiv · Oct 6, 2021Cell Biology