The Injury Response to DNA Damage Promotes Anti-Tumor Immunity
G. Sriram, L. E. Milling, J.-K. Chen, W. Abraham, E. D. Handly, D. J. Irvine, M. B. Yaffe
This study shows that ex vivo DNA-damaged tumor cells as an adjuvant enhance anti-tumor immunity when combined with immune checkpoint inhibitors, requiring live injured cells and specific signaling pathways.
bioRxiv · Apr 26, 2020 · PreprintCancer Biology