Pharmacology & ToxicologybioRxivPreprint
Simultaneous in vivo Pharmacokinetics and Pharmacodynamics of TDF Intravaginal Ring during High-dose Vaginal SHIV Challenge in Pigtail Macaques
K. Klotnik Halavaty, A. Ott, D. Maric…·T. J. Hope
This study examines TFV distribution and protection efficacy of a TDF IVR in macaques during high-dose SIV challenge, finding uneven TFV distribution and incomplete protection.
DOI 10.1101/2021.06.29.450465