Regulation of ATR activity by the RNA polymerase II phosphatase PNUTS-PP1
H. B. Landsverk, L. E. Sandquist, G. E. Rodland, B. Grallert, L. Trinkle-Mulcahy, R. G. Syljuasen
This study shows that depletion of PNUTS-PP1 increases ATR signaling, while inhibition of CDK7 reduces it, suggesting a role for RNAPII phosphatase in regulating ATR activity.
bioRxiv · Feb 16, 2018Cancer Biology