Author

L. Trinkle-Mulcahy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Gaudreau-Lapierre· 2 shared V. Mehta· 2 shared A. Pastic· 1 shared A. Ravel-Chapuis· 1 shared A. Savard· 1 shared B. Grallert· 1 shared B. J. Jasmin· 1 shared C. Zhu· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

A. Gaudreau-Lapierre

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

R. Russell, M. Akuma, M. Kim, C. Zhu, E. Wiljer, A. Gaudreau-Lapierre, L. Patterson, L. Trinkle-Mulcahy, W. L. Stanford, Y. Riazalhosseini

This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.

bioRxiv · Apr 14, 2024Cancer Biology

SPECC1L binds MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin

V. Mehta, N. Decan, A. Gaudreau-Lapierre, J. W. Copeland, L. Trinkle-Mulcahy

This paper identifies SPECC1L as a binding partner of MYPT1/PP1β and shows it regulates their distribution between microtubules and actin.

bioRxiv · Sep 9, 2022Cell Biology

Subcellular distribution of PP1 isoforms in holoenzyme complexes

V. Mehta, D. Chamousset, J. Law, S. Ooi, D. Campuzano, V. Nguyen, F.-M. Boisvert, G. B. Moorhead, L. Trinkle-Mulcahy

The paper maps PP1 isoform subcellular distribution through holoenzyme complexes using proteomic and biochemical methods, identifying c20orf27 as a novel regulatory protein and highlighting SDS22's role in PP1 localization.

bioRxiv · Sep 9, 2022 · PreprintCell Biology

LRRK2 Phosphorylates Neuronal Elav RNA-Binding Proteins to RegulatePhenotypes Relevant to Parkinson's Disease

A. Pastic, O. Negeri, A. Ravel-Chapuis, A. Savard, M. T. Trung, G. Palidwor, H. Guo, P. Marcogliese, J. A. Taylor, H. Okano, L. Trinkle-Mulcahy, B. J. Jasmin, D. Park, D. Gibbings

This study shows LRRK2 phosphorylates neuronal ELAV proteins, affecting mRNA regulation and contributing to Parkinson's disease pathology in mice.

bioRxiv · Apr 24, 2022 · PreprintCell Biology

Regulation of ATR activity by the RNA polymerase II phosphatase PNUTS-PP1

H. B. Landsverk, L. E. Sandquist, G. E. Rodland, B. Grallert, L. Trinkle-Mulcahy, R. G. Syljuasen

This study shows that depletion of PNUTS-PP1 increases ATR signaling, while inhibition of CDK7 reduces it, suggesting a role for RNAPII phosphatase in regulating ATR activity.

bioRxiv · Feb 16, 2018Cancer Biology