Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition
T. Geuens, F. A. A. Ruiter, A. Schumacher, F. L. C. Morgan, T. Rademakers, L. E. Wiersma, C. W. van den Berg, T. J. Rabelink, M. B. Baker, V. L. S. LaPointe
This study shows that encapsulating kidney organoids in a thiol-ene cross-linked alginate hydrogel reduces abnormal type 1a1 collagen deposition, improving their extracellular matrix composition and bringing them closer to clinical application.
bioRxiv · Nov 17, 2020Bioengineering