Author

A. Schumacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:development & morphogenesis· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:organoid / primary culture· 2 Research Focus:cell signaling & trafficking· 1 Assay:electronic health records· 1

Frequent Co-Authors

F. A. A. Ruiter· 2 shared F. L. C. Morgan· 2 shared M. B. Baker· 2 shared M. van Griensven· 2 shared N. Roumans· 2 shared T. Rademakers· 2 shared V. Joris· 2 shared V. L. S. LaPointe· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

F. A. A. Ruiter

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Author profile →

4 papers

Recent·Most cited

Ultrastructural comparison of human kidney organoids and human fetal kidneys reveals features of hyperglycemic culture

A. Schumacher, V. Joris, M. van Griensven, V. LaPointe

The paper compares ultrastructures of human kidney organoids to fetal kidneys, identifying hyperglycemic-like features in culture that may affect their functionality.

bioRxiv · Mar 27, 2023 · PreprintBioengineering

Enhanced microvasculature formation and patterning in iPSC-derived kidney organoids cultured in physiological hypoxia

A. Schumacher, N. Roumans, T. Rademakers, V. Joris, M. J. Eischen-Loges, M. van Griensven, V. LaPointe

This study shows that culturing kidney organoids in physiological hypoxia enhances endothelial network patterning and vascularization compared to normoxic conditions.

bioRxiv · Dec 22, 2021Cell Biology

Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial-mesenchymal transition in culture

F. A. A. Ruiter, F. L. C. Morgan, N. Roumans, A. Schumacher, G. G. Slaats, L. Moroni, V. L. S. LaPointe, M. B. Baker

This study shows that soft, dynamic hydrogels improve kidney organoid morphology and reduce epithelial-mesenchymal transition compared to stiff hydrogels.

bioRxiv · Nov 10, 2021Bioengineering

Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition

T. Geuens, F. A. A. Ruiter, A. Schumacher, F. L. C. Morgan, T. Rademakers, L. E. Wiersma, C. W. van den Berg, T. J. Rabelink, M. B. Baker, V. L. S. LaPointe

This study shows that encapsulating kidney organoids in a thiol-ene cross-linked alginate hydrogel reduces abnormal type 1a1 collagen deposition, improving their extracellular matrix composition and bringing them closer to clinical application.

bioRxiv · Nov 17, 2020Bioengineering