Casein kinase 1 dynamics underlie the PER2 circadian phosphoswitch
J. M. Philpott, R. Narasimamurthy, C. G. Ricci, A. M. Freeberg, S. R. Hunt, L. E. Yee, R. S. Pelofsky, S. Tripathi, D. M. Virshup, C. L. Partch
This study identifies a molecular switch in CK1 that regulates PER2 stability through substrate selectivity, revealing how kinase mutations affect circadian rhythms across species.
bioRxiv · Aug 14, 2019Biochemistry