Author

D. M. Virshup

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 5 Assay:proteomics· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:Drosophila· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

C. L. Partch· 3 shared R. Narasimamurthy· 3 shared S. Tripathi· 3 shared A. M. Freeberg· 2 shared B. Madan· 2 shared C. G. Ricci· 2 shared J. M. Philpott· 2 shared N. P. Harmston· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

C. L. Partch

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Author profile →

7 papers

Recent·Most cited

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling

B. Madan, S. R. Wadia, S. Patnaik, N. P. Harmston, E. J. Tan, I. B. Tan, D. W. Nes, E. G. Petretto, D. M. Virshup

This paper identifies FAXDC2 as a cholesterol biosynthesis enzyme that links Wnt/beta-catenin to RTK/MAPK signaling, showing its role in cancer progression and cellular differentiation.

bioRxiv · Dec 15, 2023Cancer Biology

Hierarchical and scaffolded phosphorylation of two degrons controls PER2 stability

J. C. Francisco, D. M. Virshup

This study investigates how two degrons in PER2 regulate its stability through phosphorylation by CK1, revealing that D1 acts as a backup degron and enables scaffolded phosphorylation in PER1:PER2 dimers.

bioRxiv · Nov 2, 2023Cell Biology

Recurrent FBXW7 mutations bypass Wnt/β-catenin addiction in cancer

Z. Zhong, D. M. Virshup

This study identifies FBXW7 mutations as a mechanism of resistance to anti-Wnt/β-catenin therapies in RNF43-mutant/RSPO-fusion cancers and shows that these tumors are susceptible to multi-CDK inhibition.

bioRxiv · Jul 28, 2023 · PreprintCancer Biology

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein Kinase 1

R. L. Harold, N. K. Tulsian, R. Narasimamurthy, N. Yaitanes, M. G. A. Hernandez, H.-W. Lee, P. Crosby, S. Tripathi, D. M. Virshup, C. L. Partch

This study shows that isoform-specific phosphorylation in the C-terminal tail of CK1δ regulates its autoinhibition and affects circadian rhythms.

bioRxiv · Apr 24, 2023Biochemistry

PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period

J. M. Philpott, A. M. Freeberg, J. Park, K. Lee, C. G. Ricci, S. R. Hunt, R. Narasimamurthy, D. H. Segal, R. Robles, Y. D. Cao, S. Tripathi, J. A. McCammon, D. M. Virshup, J. C. Chiu, C. Lee, C. L. Partch

This study shows that PER phosphorylation inhibits CK1 activity, stabilizing PER and extending circadian period through feedback inhibition.

bioRxiv · Jun 24, 2022Biochemistry

The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity

J. Yu, P. A. Bt Mohamed Yuso, P. Goh, N. P. HARMSTON, D. Epstein, D. M. Virshup, B. Madan

This study identifies RNF43 mutations that predict sensitivity to Wnt inhibitors by analyzing their functional impact in vitro and in vivo.

bioRxiv · Mar 25, 2020 · PreprintCancer Biology

Casein kinase 1 dynamics underlie the PER2 circadian phosphoswitch

J. M. Philpott, R. Narasimamurthy, C. G. Ricci, A. M. Freeberg, S. R. Hunt, L. E. Yee, R. S. Pelofsky, S. Tripathi, D. M. Virshup, C. L. Partch

This study identifies a molecular switch in CK1 that regulates PER2 stability through substrate selectivity, revealing how kinase mutations affect circadian rhythms across species.

bioRxiv · Aug 14, 2019Biochemistry