Author

L. Flores-Aldama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:electrophysiology· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1

Frequent Co-Authors

D. Bustos· 2 shared C. Colenso· 1 shared D. Cabezas-Bratesco· 1 shared G. Robertson· 1 shared J. C. Opazo· 1 shared J. Li· 1 shared K. Zavala· 1 shared L. Delemotte· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

D. Bustos

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiophysicsbioRxivPreprintMar 4, 2023

An intracellular hydrophobic nexus is critical for slow deactivation in hERG channels

W. A. Stevens-Sostre, L. Flores-Aldama, D. Bustos…·G. Robertson

This study identifies a hydrophobic nexus in hERG channels critical for slow deactivation, showing that altering hydrophobicity at this interface accelerates deactivation and links to long QT syndrome mutations.

DOI 10.1101/2023.03.04.531007

humanelectrophysiology

𝕏 PostBluesky

BiophysicsbioRxivOct 4, 2022

Intracellular helix-loop-helix domain modulates inactivation kinetics of mammalian TRPV5 and TRPV6 channels.

L. Flores-Aldama, D. Bustos, D. Cabezas-Bratesco, S. E. Brauchi

The paper identifies amino acids and interactions that determine inactivation kinetics of TRPV5 and TRPV6 channels, proposing the HLH-TDh domain association drives faster inactivation in TRPV6.

DOI 10.3390/ijms24054470

humanelectrophysiology

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintOct 17, 2019

Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels

L. Flores-Aldama, M. Vandewege, K. Zavala…·J. C. Opazo

DOI 10.1101/564997

humanmouse

𝕏 PostBluesky