J. C. Opazo

Extreme high-elevation mammal surveys reveal unexpectedly high upper range limits of Andean mice

The paper reports the discovery of Andean mice at extreme elevations, surpassing previously assumed range limits, using field surveys and genomic data.

Genomic and Radiocarbon Insights into the Mystery of Mouse Mummies on the Summits of >6000 m Andean Volcanoes

The paper reports the discovery of high-altitude mouse mummies and genomic and radiocarbon analyses showing they are recent and genetically similar to lower-altitude populations.

Sequence conservation and structural features that are common within TRP channels

The paper identifies a conserved residue fingerprint in TRP channels that may explain differences in coupling strategies among subgroups.

Whole genome duplications and the diversification of the Globin-X genes of vertebrates

This study investigates the evolution of GbX genes in vertebrates, showing that whole genome duplications have led to diverse GbX paralogs with distinct retention rates and functional implications.

Independent duplications of the Golgi phosphoprotein 3 oncogene in birds

The paper identifies three GOLPH3 genes in birds, finds independent duplications in non-paleognath groups, and highlights N-terminal variation and differential expression.

How many sirtuin genes are out there? evolution of sirtuin genes in vertebrates with a description of a new family member

The paper investigates the evolutionary history of sirtuin genes in vertebrates, identifying a new family member and showing at least eight paralogs traceable to a common ancestor.

Evolution of the DAN gene family in vertebrates

This study investigates the evolutionary history of the DAN gene family in vertebrates, revealing its monophyly and identifying new gene lineages and differential loss patterns across species.

Discovery of the world's highest-dwelling mammal

The paper reports the discovery of a mouse at 6739 m altitude, setting a new world record for mammalian altitude, highlighting underexplored high-altitude regions.

Positive selection and gene duplications in tumour suppressor genes reveal clues abouthow cetaceans resist cancer

This study identifies positive selection and gene duplications in tumour suppressor genes in cetaceans, linking them to cancer resistance, gigantism, and longevity.

Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels

The RAF oncogenes of vertebrates are ohnologs that derive from the two rounds of whole-genome duplications early in vertebrate evolution

This study investigates the evolutionary origin of vertebrate RAF genes, finding they arose from two rounds of whole-genome duplications, with B-RAF showing stronger cancer associations.

Evolution of Nodal and Nodal-related genes and the putative composition of the heterodimer that triggers the Nodal pathway in vertebrates

This study investigates the evolutionary history of Nodal and Nodal-related genes in vertebrates and infers the composition of Nodal pathway-activating heterodimers.

Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in amphibians and mammals

This study shows that GDF1 and GDF3 genes in amphibians and mammals arose from independent duplications, not from a single ancestral gene, indicating they are not orthologs.